Pharmacokinetic Drug–Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids
نویسندگان
چکیده
منابع مشابه
Drug interactions involving combination antiretroviral therapy and other anti-infective agents: repercussions for resource-limited countries.
The scale-up of antiretroviral treatment (ART) in resource-poor countries has been impressive, both in its scope and in its impact. In 2003, 400,000 people in resource-limited settings were receiving antiretroviral drugs (ARVs); by 2006, this number had increased to 2 million people [1]. Treatment of common infections occurring with HIV is also increasing, as most HIV-infected persons live in a...
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BACKGROUND Tacrolimus is an immunosuppressive drug that is a substrate of cytochrome P450 3A (CYP3A) enzymes and P-glycoprotein (P-gp). After transplantation, many pharmacological interactions have been described. Corticosteroids induce both CYP3A and P-gp activity. This study was designed to investigate the presence of a clinically significant interaction between steroids and tacrolimus after ...
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Drug interactions with digoxin are important because of this agent's narrow therapeutic index. Among the drugs that can decrease digoxin bioavailability are cholestyramine, antacid gels, kaolin-pectate, certain antimicrobial drugs and cancer chemotherapeutic agents. In selected patients, antibiotics may enhance digoxin bioavailability by eliminating intestinal flora that metabolize digoxin. Ant...
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Chloroquine combined with primaquine has been the standard radical curative regimen for Plasmodium vivax and Plasmodium ovale malaria for over half a century. In an open-label crossover pharmacokinetic study, 16 healthy volunteers (4 males and 12 females) aged 20 to 47 years were randomized into two groups of three sequential hospital admissions to receive a single oral dose of 30 mg (base) pri...
متن کاملPharmacokinetic interactions between sildenafil and saquinavir/ritonavir.
AIMS To investigate the effect of the antiretroviral protease inhibitors saquinavir (soft gelatin capsule) and ritonavir on the pharmacokinetic properties and tolerability of sildenafil and to investigate the effect of sildenafil on the steady-state pharmacokinetics of saquinavir and ritonavir. METHODS Two independent, 8 day, open, randomized, placebo-controlled, parallel-group studies (conta...
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ژورنال
عنوان ژورنال: Annals of Transplantation
سال: 2018
ISSN: 2329-0358
DOI: 10.12659/aot.906164